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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Frontiers of Medicine doi: 10.1007/s11684-023-1020-z

Abstract: Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomicanalysis (n = 50) of retroperitoneal dedifferentiated liposarcoma (RDDLPS) and retroperitonealData analysis mainly revealed that glycolysis, purine metabolism, pyrimidine metabolism and phospholipid

Keywords： RLPS     proteomics     metabolomics     lipidomics     metabolism    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omicsanalysis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolismThus, this study establishes a new omics analytical method integrated with bioinformatics analysis for

Keywords： arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced arthritis     omicsanalysis    

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Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: Omics technologies allow high-throughput screening of sepsis biomarkers.This review paper serves as a reference for future studies that employ an integrated, multi-omics approach

Keywords： sepsis     biomarker     genomics     transcriptomics     proteomics     metabolomics    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Engineering 2023, Volume 30, Issue 11,   Pages 30-31 doi: 10.1016/j.eng.2023.05.005

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: Recently, the rapid development of omics techniques (e.g., genomics, proteomics and transcriptomics)review, we introduce experimental and computational identification methods of PPIs, popular PPI network analysisWe anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Technology and Equipment of Big Data on Crop Phenomics

Wen Weiliang , Guo Xinyu, Zhang Ying , Gu Shenghao, Zhao Chunjiang

Strategic Study of CAE 2023, Volume 25, Issue 4,   Pages 227-238 doi: 10.15302/J-SSCAE-2023.04.015

Abstract: this area is summarized from five aspects: data acquisition hardware, data transmission, data analysisapplication in China are analyzed from the perspectives of high-throughput acquisition and intelligent analysis

Keywords： crop phenomics     phenotyping big data     technology and equipment for phenotyping     multi-omics    

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The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery Review

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Engineering 2024, Volume 32, Issue 1,   Pages 19-29 doi: 10.1016/j.eng.2023.09.011

Abstract: Furthermore, an AI-driven multi-omics integration strategy for GPCR ligand discovery that combines informationfrom various omics disciplines was proposed.

Keywords： G protein-coupled receptor     Ligand     Artificial intelligence     Multi-omics     Drug discovery    

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MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Engineering 2022, Volume 16, Issue 9,   Pages 162-175 doi: 10.1016/j.eng.2021.07.020

Abstract: Moreover, we performed comprehensive transcriptomics, proteomics, and metabolomics analysis on the potentialMixOmic DIABLO analysis showed a close correlation and strong cluster consistency between the proteomicsThe integrated multi-omics and co-enriched pathway analysis showed that miR-516a-3p regulates the metabolic

Keywords： Hepatocellular carcinoma     miRNA cluster     Exosome     Multi-omics    

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Expanding the Scope of Multivariate Regression Approaches in Cross-Omics Research Article

Xiaoxi Hu, Yue Ma, Yakun Xu, Peiyao Zhao, Jun Wang

Engineering 2021, Volume 7, Issue 12,   Pages 1725-1731 doi: 10.1016/j.eng.2020.05.028

Abstract: Numerous traditional multivariate approaches such as principal component analysis have been used broadlyin various research areas, including investment analysis, image identification, and population geneticstructure analysis.Our method extensions provide valuable guidelines for future omics research, especially with respect

Keywords： Multivariate regression methods     Reduced rank regression     Sparsity     Dimensionality reduction     Variable selection    

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Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp. 1647: Pseudo-Tetrapeptides Article

Hongmin Sun, Xingxing Li, Minghua Chen, Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li, Jian-Dong Jiang, Bin Hong, Shuyi Si

Engineering 2022, Volume 16, Issue 9,   Pages 176-186 doi: 10.1016/j.eng.2021.05.010

Abstract: We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell (antiSMASH) analysis of its genome sequence revealedThrough bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene, clusterBioactivity-based molecular networking analysis of mass spectrometric data from different recombinantBy integrating multi-omics data, we discovered a number of novel antiviral pseudo-tetrapeptides produced

Keywords： Multi-omics     Anti-influenza A virus     Anti-coronavirus     Streptomyces sp. 1647     Pseudo-tetrapeptides    

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract: molecular interface between host and microbiota with concurrent metabolomics and microbiome composition analysis

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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15th International Congress for Stereology and Image Analysis 第十五届国际体视学与图像分析学术会议

Conference Date: 27 May 2019

Conference Place: 丹麦/奥胡斯

Administered by: 国际体视学与图像分析学会(ISSIA)

Title Author Date Type Operation

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omicsanalysis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Journal Article

Technology and Equipment of Big Data on Crop Phenomics

Wen Weiliang , Guo Xinyu, Zhang Ying , Gu Shenghao, Zhao Chunjiang

Journal Article

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Journal Article

MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Journal Article

Expanding the Scope of Multivariate Regression Approaches in Cross-Omics Research

Xiaoxi Hu, Yue Ma, Yakun Xu, Peiyao Zhao, Jun Wang

Journal Article

Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp. 1647: Pseudo-Tetrapeptides

Hongmin Sun, Xingxing Li, Minghua Chen, Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li, Jian-Dong Jiang, Bin Hong, Shuyi Si

Journal Article

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article

15th International Congress for Stereology and Image Analysis 第十五届国际体视学与图像分析学术会议

27 May 2019

Conference Information

黄幼麟: Dynamic Consumer Preferences for Electric Vehicles — A Longitudinal Analysis (2020-7-12)

10 Jun 2022

Conference Videos

Toshio Fukuda: Bio Cell Analysis and Assembly by Micro and Nano Robotic Technology（2019-8-25）

福田敏男(院士)

20 Jan 2021

Conference Videos